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Compared with saline and free-drug controls, TBP-NP-treated mice demonstrated significantly improved range of motion and enhanced mechanical properties, confirming effective tendon-specific targeting and functional repair ( In vitro , PDGF-BB cmRNA enhanced tendon cell proliferation and migration, while IL1RA cmRNA reduced pro-inflammatory cytokine expression
The essential nature of this reaction was established with the development of GGT knockout strains of mouse (Lieberman et al., 1996)
doi: 10.1080/15384101.2019.1597506 59 ZhangYShiJLiuXFengLGongZKoppulaPet al
