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Monteleone G, Pender SL, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT

Ferroptosis occurs in animal models of arsenic-induced pancreatic dysfunction ( via the endoplasmic reticulum (ER) stress-related PERK pathway (77)

After exposure to oxidative stress (i.e., following hypoxia or inflammation), KEAP1 undergoes a conformational alteration, which prevents it from binding to Nrf2 and leads to the release, accumulation, and translocation of Nrf2 into the nucleus [1, 91] (Fig

More importantly, although we have collated the evidence on the penetration of hepatokines into the BBB, variations in research approaches and indirect measurements introduce uncertainties