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The injection is well tolerated by most people, and some do not feel it

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Hamann, J., Wernicke, C., Lehmann, J., Reichmann, H., Rommelspacher, H., & Gille, G

GLP-1 signaling and hepatic steatosis Human hepatocytes express little or no GLP-1 receptor, so most experts believe semaglutides liver benefits are largely indirect mediated by weight loss, reduced adipose lipolysis, improved insulin sensitivity, lower glucotoxicity, and decreased hepatic lipogenic drive rather than by direct receptor engagement on liver cells