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Sci Rep (2021) 11(1):16767

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Activation of this pathway disturbs lipid synthesis and breakdown, causing abnormal lipid accumulation and metabolic dysfunction in hepatocytes ( CHB is also characterized by T-cell exhaustion, which is worsened by alcohol and includes up-regulation of PD-1, CTLA-4, and TIM-3 ( Paradoxically, controlled low-dose alcohol exposure enhances dendritic cell (DC) maturation and exosome-driven T-cell activation in CHB, countering typical immunosuppression