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Introduction Mesoporous silica nanoparticles (MSNs) have elicited a high level of interest among scientists due to their outstanding physicochemical characteristics, which include superior surface area, tunable pore size, thermal stability, and easy accessibility to surface functionalization [1,2,3]

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Nevertheless, given that iodoethane is a very good substrate also for the orthologue enzyme AgGSTE2-2 (data not shown) and this enzyme is the key enzyme responsible for DDT resistance in this species [4], there is no reason to believe that this assay will not work for Anopheles mosquitoes too