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An increase in activated microglia has been observed in both PD patients and healthy older people, indicating that various triggers might induce a proinflammatory shift with age (57)

Increasing CNS uptake of therapeutic agents has focused on increasing passive diffusion through liposomal encapsulation and transcytosis through conjugation with polymeric nanoparticles (Pandian et al., 2022

Patient education booklet co-created by CU, Colorado patients and experts

It has also been shown that lowering hyperoxia in the retina after rod death, by placing the RP mice in a hypoxic chamber result in decreased oxidative damage on cones, and better cone vision [9]