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But if you come back every week for a month or so you'll notice a big difference in your overall level of energy." So the very first time someone gets a B12 shot they probably won't feel much of an effect, even though they might experience a bit of an energy boost after the very first one, but it usually only lasts for about a week

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doi: 10.1186/s12967-019-1909-0 270 TadaS.OkunoT.ShimizuM.SakaiY.Sumi-AkamaruH.KinoshitaM.et al