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This central action drastically decreases sympathetic outflow from the central nervous system to the heart, kidneys, and peripheral vasculature (Figure 1)(Patel and Saadabadi, 2025)
The pigmentation was around my jaw area and it was very pronounced

Importantly, skeletal muscle atrophy is a hallmark of rodent myocardial infarction models of congestive heart failure

PMID 25912534
