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The canonical pyroptosis pathway is initiated by the activation of the NLRP3 inflammasome complex, which includes NLRP3, the adaptor protein ASC containing the CARD domain, and pro-caspase-1 [65]

While most acute wounds heal within days to a few weeks, chronic wounds often remain in a prolonged inflammatory state, exhibiting elevated protease activity and impaired progression through these healing phases [23,24,25]
