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Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., The sub-organellar localization of GCL raises questions about redox regulation of glutathione biosynthesis in plants

Hypogonadism is characterized by low levels of testosterone due to disruption of the HPG axis

Schuettengruber B, Martinez AM, Iovino N, Cavalli G

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