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doi: 10.1093/nutrit/nuab017 23
All these components are shaped by the interplay between genetic factors and lifelong experience: in particular, physical exercise, healthy diet and intellectual engagement increase cognitive reserve, whereas diseases and stressors that lead to the accumulation of pathological burden decrease it 110,111,112

Type 1 DM (T1DM) is distinguishable from T2DM because the former is an autoimmune disorder where pancreatic beta-cells are destroyed, while the latter is characterized by progressively dysfunctional glucose regulation attributable to a combination of insulin resistance and pancreatic beta-cell destruction (11, 12)

Steel DM, Whitehead AS
