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The only report of the effects of exercise on cerebrospinal fluid studied control subjects who had lumbar puncture 1 h after running for 90 min 21

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Large-scale randomised controlled trials, including the STEP 1 trial (Wilding et al., NEJM 2021) for semaglutide 2.4 mg, have demonstrated clinically meaningful and sustained weight loss in adults with obesity or overweight with weight-related comorbidities