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APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target

[DOI] [PubMed] [Google Scholar] Diaz Vivancos P., Wolff T., Markovic J., Pallard'O F.V., Foyer C.H

Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

Biological samples preparation 50 L of plasma was diluted with 150 L of 0.2 mol/L phosphate buffer, pH 7.8, and treated with 5 L of mixture of 0.1 mol/L BCPB and 0.125 mol/L TCEP for 15 min