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Mitochondrial failure presents as low ATP generation and reduced release of ROS ( + T cells produce excess citrate and transport it out of the mitochondria into the cytosol ( via activation of AMPK ( lo status of RA T cells is aggravated by suppressed glycolysis

Ferroptosis is an iron-dependent nonapoptotic type of regulated programmed cell death that is closely related to the pathophysiological processes underlying tumorigenesis, neurological diseases and other conditions

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