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[PubMed: 3413344] 17

Small clinical studies suggest it may provide pain relief and functional improvements, but the lack of standardized protocols and high-quality RCTs limits clinical adoption (34)
These gene expression changes indicate that the plant might sense the presence of exogenously applied ITC, reduce the biosynthesis of GSLs and prevent the generation of endogenous ITC from GSL breakdown by favouring the generation of nitriles and their further catabolism by nitrilases

Drug Metab Rev 42:380401
