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[DOI] [PMC free article] [PubMed] [Google Scholar] Begas P, Liedgens L, Moseler A, Meyer AJ, Deponte M

(2019) 6:e562

Thorax 66 , 764768 (2011)

Pharmacokinetics: metabolized through the hepatic cytochrome P450 system Side Effects / FDA Warning: The FDA issued a black box warning to indicating an increased risk of heart failure with both pioglitazone & rosiglitazone Long term therapy is associated with a small increase in HDL & LDL & a decrease in Triglycerides The triglyceride lowering effect of pioglitazone is greater than that of rosiglitazone, presumably due to its stimulatory effects on PPAR- (which may be due to decreased osteoblast formation)