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Funct Integr Genomics 8:187198 Zhang Y, Liu J, Zhou Y, Gong T, Wang J, Ge Y (2013) Enhanced phytoremediation of mixed heavy metal (mercury)organic pollutants (trichloroethylene) with transgenic alfalfa co-expressing glutathione S-transferase and human P450 2E1

In view of (1) the large number of mammalian cysteine S -conjugate -lyases identified to date, (2) their overlapping specificities, (3) their widespread occurrence in tissues, (4) their presence in different subcellular compartments (e.g., cytosol, mitochondria, and peroxisomes), and (5) the increasingly recognized wide scope of these reactions, the potential of these enzymes for generating toxic products in different subcellular compartments, not only in the kidneys but also in other tissues, is highly significant

Abdali D, Samson SE, Grover AK

These hormonal changes can exacerbate pigmentation disorders