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& Jnicke, R

[PUBMED Abstract] Mattano LA, Devidas M, Loh ML, et al.: Development of osteonecrosis and improved survival in B-ALL: results of Children's Oncology Group Trial AALL0232

Based on studies carried out on murine models, the authors hypothesised that the milk pro-oxidant galactose (component of lactose) may be one of the main causes of these observed effects ( Reference Cui, Zuo and Zhang 116 Reference Hao, Huang and Gao 118 ) , with the increase in oxidative stress specifically associated with a lower life expectancy in animals ( Reference Cui, Wang and Zuo 119 ) and with chronic diseases in humans ( Reference Utkualp and Ozdemir 120 , Reference Moylan and Reid 121 )

Oral peptides, however, must survive the digestive tract and be absorbed into circulation, making their effectiveness highly dependent on formulation