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The proposed assay was validated through an observational study in a cohort of 1,031 CRC patients (NCT02540850), demonstrating that the SE of the newly SEPT9 assay was enhanced when combined with carcinoembryonic antigen testing (SE: 86.4%) or fecal immunochemical testing (SE: 94.4%) [273]
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These studies further underscore the role of AhR ligands in intestinal inflammation, suggesting that Trp has potential in alleviating IBD intestinal inflammation by inhibiting ferroptosis
