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Studies exploring molecular mechanisms remain relatively few and it is still not clear how Keap1-NRF2 dissociation is deregulated in NSCs from physiological to pathological conditions such as neuroinflammation
Functionally, CD70 can trigger the reactivation of PI3 K/AKT and MAPK/ERK signaling pathways to confer TKI tolerance
Their findings revealed that intracellular copper ions are key factors in NLRP3 inflammasome assembly and subsequent activation of cytokines such as caspase-1 and IL-1
