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Among approved drugs, participation of patients over 65 has ranged from 10 percent in 2014 to 39.9 percent in 2020, indicating a consistent increase in the share of elderly participants in trials resulting in FDA approval during this period (2021 data are yet incomplete)
Furthermore, M3 muscarinic ACh receptor overexpression was observed to reduce the incidence and mortality of arrhythmia after myocardial ischemia-reperfusion injury
doi: 10.1191/096032701680350587
