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Tumor suppressors and oncogenes play essential roles in regulating glutamine metabolism, and their activity can profoundly impact the function of glutamine and its metabolites in cancer cells [47] (Figure 1)

Type II collagen, predominantly found in cartilaginous structures, provides a resilient framework that enables these tissues to withstand compressive forces [52], also known as reticular fiber, which is present in connective tissues, contributing to their integrity through its flexible nature [53, 54]

Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis

A central limitation lies in the incomplete understanding of the spatiotemporal dynamics of ROS generation in vivo