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(4) Safety Evaluation: Encompassing biocompatibility tests required by the ISO 10,993 standard, including local safety (nasal mucosal histopathology, olfactory electrogram), systemic toxicity (RES organ accumulation, immunogenicity), and long-term safety (NHP repeated-dose studies), establishing a predictive model of material characteristics-biological interface reactions-chronic pathological outcomes [25, 27, 30]
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26A), luminol (Fig
Existing polyphenol interventions show that daily intake (over 4 to 8 weeks) of berry-, grape-, or apple-derived products can modestly lower fasting TMAO (3639), yet none of these has examined how polyphenol-rich interventions influence full 48-h post-OCC plasma TMAO profiles from precursors such as L-carnitine
