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This intervention markedly enhances the antitumor efficacy of CAR-T cells, CD8 T cells, and mRNA vaccines, offering a promising breakthrough for overcoming resistance in immunotherapy-refractory solid tumors such as MSS CRC

Of note is evidence showing that prolonged food deprivation does not increase systemic inflammation but does result in increased muscle TNF mRNA and protein levels in elephant seals (Vzquez-Medina et al., 2010

In the TME, the ectoenzyme CD38 is a major NADase expressed on many immune cells, including myeloid cells

2012;302:C17805
