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An important consideration is that TRS patients who responded to clozapine showed a lower impact of KYNA on multiple symptom domains compared to first-line responders, suggesting the greater involvement of KYNA in refractory symptoms [7]

Unit dosage form as used herein refers to physically discrete units suited as unitary dosages for the subjects to be treated

Circ Res 90:966973 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C et al (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele