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Anti-4-1BBPDL1 bispecific antibody reinvigorates tumor-specific exhausted CD8+ T cells and enhances the efficacy of anti-PD1 blockade

The wounds pictures were taken over the certain days and the remaining wound areas percentage was measured according to the following equation: Histopathology study Animals on mentioned days were sacrificed by ketamine overdose injection, and the collected tissues were placed in a 10% formalin solution and fixed for 24 h

Cold water immersion falls between these extremes, with 10-15 minute sessions at 10-15 degrees Celsius representing common athletic protocols

For viral infection assays, target cells were incubated with the virus for 1 h, after which the medium was replaced with fresh medium supplemented with 2% FBS until further experimentation