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The ligandin function of GSTs Because of exhibiting a ligand binding function, glutathione tranferases, have been known as ligandin, a function, which involves the noncovalent binding of nonsubstrate hydrophobic ligands such as heme, bilirubin, various steroids, and conceivably some lipophilic anticancer drugs as well
Domain II makes up the glutamate-binding domain, and is composed of mainly beta sheets involving residues 182-399 (5)
