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To identify the binding interface of the B-017 with BAX and the BAX/BNIP3, we performed photo-cross-linking with B-017 carrying a photo-reactive-p-benzoyl-L-phenylalanine (BpA) moiety at the C-terminus (B-017-BpA), followed by mass spectrometry (XL-MS) 41

In contrast, radiation promotes cuproptosis by increasing mitochondrial copper through upregulation of the copper importer solute carrier family 31 member 1 (SLC31A1, also known as CTR1) while simultaneously depleting mtGSH, thereby shifting copper homeostasis toward toxicity 170

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