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In addition to BRCA genes, mutations in other high-penetrance genes such as TP53 (associated with Li-Fraumeni syndrome) and PTEN (linked to Cowden syndrome) have been found to be associated with familial breast cancer, as these genes are heritable, keeping women at potential risk to develop cancer during their lifetime ( PALB2, ATM , and CHEK2 (63)

Vomiting was noteable at 1 mg/day in the PRESTO-study, as was the occurrence of dyskinesias but such adverse reactions have not been described in other clinical trials like the LARGO-trial

doi: 10.1038/srep21934 90 ShomaliA.AliniaeifardS.DidaranF.LotfiM.MohammadianM.SeifM.et al
