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In renal epithelial cells, TRPV4 channel activation results mainly from hypotonic cell swelling, which suggests that TRPV4 acts as an osmosensor and could play a critical role in renal ischemic/reperfusion injury 41,42 and in autosomal recessive polycystic kidney disease 43

They do not necessarily contain stable lumen formation, pericyte support, normal basement membrane deposition, vessel-wall maturation, or functional perfusion