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Transferrin-conjugated systems enhance blood-brain barrier penetration in glioblastoma, elevating brain curcumin concentrations 8-fold and suppressing tumor growth by 45%

A larger randomized, placebo-controlled intervention trial (the SELECT study) in more than 35,000 middle-aged and selenium-replete men, randomized to receive selenium (in the form of selenomethionine, 200 g/day) and/or vitamin E supplementation, was halted because of concerns regarding an increased risk of type 2 diabetes mellitus with selenium and increased risk of prostate cancer with vitamin E (84, 85)

The peptide is stable in gastric acid, which makes oral administration viable for gut-targeted applications, a property that distinguishes it from many other therapeutic peptides that degrade before reaching target tissue

Current research shows that long-term use of B12 injections is safe for healthy individuals