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The numerical simulations show a distinct reduction in M2 density when optimal control is applied, as demonstrated in Fig

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The Gut-Joint Communication Axis in Rheumatic Disease Development Rheumatoid Arthritis RA is a physically debilitating autoimmune disorder characterised by excessive systemic inflammation leading to the progressive destruction of joints among other complications (McInnes and Schett 2011
this in turn promotes axon degeneration [30,31,32]