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It undergoes extensive hepatic biotransformation, including oxidative cleavage mediated by CYP enzymes, while methylation reactions are probably mediated by catechol- O -methyltransferase

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10.1016/j.immuni.2018.06.016 [DOI] [PMC free article] [PubMed] [Google Scholar] 159.Yang H, Huang Y-X, Xiong P-Y, Li J-Q, Chen J-L, Liu X, et al
