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Following this, BH4 can be recycled back from its oxidized form, dihydrobiopterin, with the help of dihydrofolate reductase using NAD(P)H (182,183)

Genetic predictors of interindividual variability in hepatic CYP3A4 expression

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Targeted deletion of the MC4R in mice resulted in hyperphagia, reduced energy expenditure, and obesity [4]
