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Redox homeostasis controls multiple cellular signaling pathways including proper functioning of the mitochondria and endoplasmic reticulum (ER) compartments, calcium regulation, axonal transport, autophagy, protein folding, and proteostasis (Grlach et al., 2006

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Painful diabetic neuropathy is a multi-factorial condition as several pathophysiological mechanisms can simultaneously occur and influence the onset and the course of symptoms