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doi: 10.1111/febs.15214

But the aching gets so severe sometimes that patients require drugs to soothe the pain

Similarly to colchicine, podophyllotoxin binds the colchicine site at the interface of - and -tubulin, inhibits the assembly of tubulin into microtubules, blocks the cell cycle in G2/M phase, and finally leads to mitosis arrest 57,58

[44] Structurefunction relationships [edit] In terms of structure, GPCRs are characterized by an extracellular N-terminus, followed by seven transmembrane (7-TM) -helices (TM-1 to TM-7) connected by three intracellular (IL-1 to IL-3) and three extracellular loops (EL-1 to EL-3), and finally an intracellular C-terminus