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Description
In colonic epithelial cells, TMAO induces NF-B-dependent upregulation of IL-8 and TNF-, disrupting tight junctions and increasing permeability (102, 103)
Sawicka AK, Renzi G, Olek RA
For example, one study followed 170 women with this syndrome from the time they started taking carnitine or a placebo until they had their first positive pregnancy test
Elevated TMAO levels have been linked to a number of diseases, including cardiovascular and neurological disorders, renal disease, metabolic syndrome, obesity, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cancer, and severe COVID-19
