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Investigations in preclinical models, including those involving muscle degeneration, suggest that IGF-1 derivatives may support the preservation of muscle cells and influence key regulatory proteins such as MyoD

doi: 10.1007/s00018-020-03536-5 [DOI] [PMC free article] [PubMed] [Google Scholar] 27

As SNCA transcription is regulated by DNA methylation at SNCA intron 1, a level in the brain that differs between PD patients and controls, they created a technique for targeted DNA methylation editing within intron 1 using an all-in-one lentiviral vector

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