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Current approaches for multi-cellular system modeling for cancer have been recently reviewed [176] and give an interesting basis for future analysis of glutathiones role in these systems
doi: 10.1016/j.jaci.2012.10.026 [DOI] [PMC free article] [PubMed] [Google Scholar] 34
Importantly, the treatment was well tolerated, with no occurrence of cytokine release syndrome (CRS) or neurotoxicity (80)
While the preclinical safety profile appears favorable (few adverse effects reported in animal studies), this does not guarantee the same in humans, especially with prolonged use
