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Common Side Effects Injection site reactions Headache Flushing Mild fluid retention Metabolic and Hormonal Considerations Potential alterations in glucose metabolism Elevated IGF-1 levels Theoretical risk of promoting tumor growth in predisposed individuals Key Limitation Most safety data comes from: Pediatric GH deficiency populations Adults with endocrine disorders There is limited long-term data in healthy, high-performing athletes

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Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2