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Additionally, there was no significant difference in plasma NO observed in a study of swimmers who took 8 g of Cit, Arg or placebo supplements per day for eight days [127]

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The intrinsic pathway can be triggered either as a result of mPTP opening, or activation of the proapoptotic proteins of the B-cell lymphoma 2 (Bcl-2) family, Bax and Bak [192] after the removal of the block of antiapoptotic proteins Bcl-2 and Bcl-XL [193]
