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The results obtained showed that curcumin exerted inhibitory effect on the proliferation of HCT-116cells that increased progressively in a concentration- and time-dependent manner when assessed using the CCK-8 assay
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9 , 36 Consequently, this induces a pseudo-first-pass effect that interferes with drug absorption 37 and negatively affects the pharmacokinetic and pharmacodynamic profiles of the drugs

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Their study illustrates the critical importance of modeling nanoparticle biological interactions such as cellular uptake, immune evasion, and in vivo degradation patterns early in the design phase
