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Description
Despite all advances in neuroscience in recent decades, age-associated cognitive decline resulting from neurodegenerative processes in the brain remains a challenge for researchers and clinicians due to the highly complex nature of its pathogenesis
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While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful
