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GoudarziHKimuraHKimuraHMakitaHMatsumotoMTakeiNet alEffects of obesity on CC16 and their potential role in overweight/obese asthma

Impaired kidney function is also associated with increased IGFBP levels (e.g., IGFBP-1, -2, -3, -4, and -6) (75, 77) and IGFBP-3 protease activity, which subsequently increases low-molecular-weight IGFBP-3 fragments (78), most likely due to a compromised renal IGFBP-clearance ( Figure 4 )

Volta, De Giorgio 2012)

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Fukai T., Ushio-Fukai M
