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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

Not for Diagnostic or Therapeutic Applications

Despite its intricate and context-specific function within the CNS, exhibiting both protective and detrimental impacts on neuronal and glial survival and function, LIF signaling is crucial for the maintenance of the nervous system (reviewed in: 34 )

This unmet need for alternative constructs has led to the exploration of sdAbs