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Combined curcumin and exercise intervention in hyperlipidemic rats downregulates pyroptosis genes (NLRP3, ASC (Apoptosis-associated speck-like protein containing a CARD), caspase-1) by inhibiting TLR4/MyD88/NF-B (Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor kappa-B) signaling and reducing serum IL-1 (Ramos et al., 2016)
doi: 10.1016/j.plaphy.2006.10.021
In addition to B12, other B vitamins can play a role in neuropathy treatment
If you are simply treating a deficiency, then you may only need to receive injections once or twice a year
