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(2018) demonstrated that AgNPs biosynthesized using Salacia chinensis bark extract, administered intraperitoneally at 5 mg/kg daily for 2 weeks in SCC xenograft-bearing mice, inhibited tumor growth by 54% and decreased proliferation marker Ki-67 expression, while sparing normal tissue architecture (Jadhav et al., 2018)

Although this metabolic pathway has been more extensively studied in tissues such as the liver, the unique high CYP1B1 environment in fibroid tissue suggests that local metabolism of E may constitute an intrinsic source of ROS [46]

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Ideal candidates for this treatment are usually over 40