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Therefore, UBB+1 is involved in both secretase-dependent and independent pathways for A generation and this could be a reasonable explanation as to why UBB+ conjugated protein aggregation has been found to be associated with A plaques in transgenic UBB+1 AD brain (van Leeuwen et al., 2006

The risk was calculated using multivariate logistic regression analysis and after adjusted for confounders such as high BMI and smoking
Biochem J 440:6371

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