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509 AS-252424 is a specific and targeted ACSL4 inhibitor that binds directly to the glutamine 464 of ACSL4 to inhibit its enzymatic activity, thereby inhibiting lipid peroxidation and ferroptosis, effectively alleviating ferroptosis-mediated organ damage in mouse models, including I/R-induced kidney injury and acute liver injury

Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH

Statements Data availability statement The data presented in the study are deposited in the NCBI repository, available at: Author contributions GY: conceptualization, writing-review and editing, and funding acquisition

While some studies suggest interactions with gut-related pathways, no clinical conclusions can be drawn at this time