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151 Developing nanomedicine with desired characteristics to overcome barriers is a challenging task, which historically relied on a trial-and-error approach

It should be noted that uptake of Se into the brain compartment without a balanced Se-discharge mechanism could finally lead to local, brain-compartment related Se-overexposure

Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

10.1038/s41401-020-0450-2 46 DuL.GuoC.ZengS.YuK.LiuM.LiY